Mega Python vs. Gatoroid is a 2011 monster, science-fiction, disaster film by The Asylum, directed by Mary Lambert, and starring pop singers Debbie Gibson and Tiffany.

A group of animal activists, consisting of Dr. Nikki Riley, Gia, and Ben, breaks into a house and steals dozens of exotic pythons before setting them free into the Florida Everglades.

Due to the threat of the invasive species, Park Ranger Terry O’Hara issues permits to the local hunters to exterminate the pythons – much to Nikki's dismay.

After seeing a python and an alligator battle each other, Diego urges Terry to cancel a fund-raising event that is to be held that night to help restore a nearby estuary, but his cries fall on deaf ears.

At the fund-raising event, Nikki shows up at the VIP tent uninvited, threatening to blackmail Terry with a disc containing footage of her feeding the alligators.

However, when their plane crashes on a highway after being hit by a python, Terry takes the remaining bottles of pheromones and drives an abandoned car to lure the reptiles away from the Turkey Point Nuclear Power Plant.

Ken Tucker of Entertainment Weekly said in his review that the film "did something that other stalwarts of this genre, such as Sharktopus and Dinocroc vs. Supergator, did not do: It called attention to how bad, campy, and trashy it was; the actors did everything except wink coyly at the camera.

"[5] Jared Rasic of CHUD.com gave the film two out of five stars, commenting, "this movie knows exactly what it is and doesn’t try to surprise you with any sort of quality element to make the time you spent watching this have meaning.