Through human interference of the local environment, the megapiranha manage to escape from their isolated spot and swim downstream, killing all that cross their path.
Throughout the chase, Fitch alternates driving a Toyota Camry and Hyundai Elantra while Diaz is seen at different points in a GMC Jimmy, Chevrolet Suburban, Suzuki XL-7, and Ford Explorer.
They eventually reach south Florida, where they kill at least five Puerto Ricans on a beach and manage to blow up two hotels.
An army of SCUBA divers armed with guns would make the huge fish bleed, causing them to enter a feeding frenzy and kill each other.
The Colonel aims to get revenge on Agent Fitch and throws a rope into the water to trick him into climbing up into the enemy helicopter.
Fitch then uses a homing beacon (which is actually a canister of CO2) to attract a megapiranha, jumping out of the helicopter shortly before it is consumed by the fishy behemoth.
The other megapiranha converge on the bloodshed and Fitch is able to escape as the piranha enters a feeding frenzy and begin tearing each other to pieces, seemingly resulting in them wiping themselves out.
Dread Central wrote about the film: "Now, the question becomes whether Mega Piranha means we should expect a super-sized piranha a la Asylum's Mega Shark Versus Giant Octopus or if they are basing their film around the prehistoric Megapiranha, a toothier, three-foot version of the carnivorous fish that became extinct millions of years ago.
[9] The film reached a 2.2 million audience for its April 10 premiere, making it the channel's most-watched movie of the year.