The second Megacles was a member of the Alcmaeonidae family, and the archon eponymous in 632 BC when Cylon made his unsuccessful attempt to take over Athens.
Megacles was convicted of killing Cylon's supporters (who had taken refuge on the Acropolis as suppliants of Athena) and was exiled from the city, along with all the other members of his genos, the Alcmaeonidae.
The third Megacles, the grandson of the above eponymous archon, son of Alcmaeon and member of the Alcmaeonidae family, was an opponent of Pisistratus in the 6th century BC.
[2] This Megacles earlier had competed with Hippocleides, a future archon of Athens, to marry Agarista, the daughter of Cleisthenes of Sicyon.
The younger son was Cleisthenes, who was allegedly the grandfather of Deinomache (or Dinomache), mother of Alcibiades (d. 404 BC).
The fourth Megacles, grandson of the above, son of Hippocrates, and nephew of Cleisthenes is sometimes described as the father of Deinomache and thus the maternal grandfather of Alcibiades.