Megahippus is an extinct genus of large Anchitheriine horses found throughout the southern portion of the United States during the middle Miocene.

[2] Unlike the incisors of other anchitheriines like Hypohippus, they would have been large and high-crowned.Between the two species, there is evidence of a trend of the animal's premolars shrinking overtime with them being larger proportionally in M.

[3] Both Megahippus and Hypohippus show a general trend in the increase in frequency of conchets in their upper cheek teeth potentially due to the segregation of the section when compared to the earlier Anchitherium.

[3] The limb morphology of Megahippus is similar to those seen in living equines, having adaptations towards the restricted movement of the fetlock.

[8] Based on wear and morphology seen in the incisors of Megahippus, this animal was a more specialized browser than other genera.