Megalocoelacanthus dobiei is an extinct species of giant latimeriid coelacanth lobe-finned fish which lived during the Lower Campanian epoch until possibly the early Maastrichtian in the Late Cretaceous period in Appalachia, the Western Interior Seaway and Mississippi Embayment.

Although no complete skeleton is known, careful examination of skeletal elements demonstrate it is closely related to the Jurassic-aged coelacanthid Libys.

The species is named for herpetologist James L. Dobie.

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