Clark also worked in a corporate venture fund with Advent International in Boston.

[8][11][12] Under her leadership CSIRO was credited for a number of new ventures, including wireless research.

[15] Clark was one of the Directors of Rio Tinto in May 2020 when the mining company deliberately destroyed the Australian Aboriginal sacred site at Juukan Gorge – the only inland site in Australia to show signs of continuous human occupation for over 46,000 years.

"[17] The Rio Tinto board noted in response to the vote that "Rio Tinto acknowledges that the reduced vote for Dr Clark's re-election compared to previous years reflects the fact that, as chair of the Sustainability Committee at the time that the rock shelters at Juukan Gorge were destroyed, Dr Clark shares accountability for the failings in the areas of communities and social performance that led to those events occurring.

[19][20] In the 2014 Queen's Birthday Honours List, Clark was appointed a Companion of the Order of Australia (AC), for "eminent service to scientific research and development through fostering innovation, to science administration through strategic leadership roles, and to the development of public policy for technological sciences".