She received the Frances Pomeroy Naismith Award from the Women's Basketball Coaches Association as the best senior player under 5 ft 8 in (1.7 m).

Duffy spent her rookie season with the Lynx backing up Amber Jacobs; she averaged 3.4 points, 1.2 assists and 12.5 minutes per game in 2006.

She signed with the Los Angeles Sparks on April 30, but she was waived on May 18 in the final preseason roster cutdown.

A free agent most of the 2007 season, Duffy was re-signed by the Lynx on August 7, due to Kathrin Ress' departure to train with the Italian National Team.

[10] In 2009, Duffy retired from play and entered the coaching ranks as an assistant under Kim Barnes Arico at St. John's.

In two seasons with the Redhawks, Duffy accumulated a 44–20 overall record, including a 25–11 mark in league play.

[13] Through three seasons, she boasts the best winning percentage of any coach in the program's history, going 66–26 (.717) overall and 40–16 (.713) in BIG EAST play.