She returned as a junior for 2005–2006 and was an Honorable Mention Kodak and Associated Press All-America, ACC Defensive Player of the Year.

Harding finished her college career with 1,298 points, 25 blocks, 579 assists, 296 steals and 565 rebounds in 128 games (school record).

Despite her tremendous career numbers, contributions and a 32–2 record, she left Duke without winning an NCAA championship.

Harding's senior season at Duke ended with the Rutgers Scarlet Knights' upset of the Blue Devils in the Sweet Sixteen round of the NCAA tournament, a one-point upset sealed by Harding's missing two free throws with 0.1 seconds remaining in the game.

[6] She was named to the WNBA All-Rookie Team by the end of the season and finished with averages of 11.7 points and 3.9 assists per game.

Along with Izi Castro Marques, Érika de Souza, Sancho Lyttle and Angel McCoughtry, the Dream were a championship contender in the league.

On August 4, 2013, Harding had 11 points along with a career-high 14 assists in a regular season victory against her other former team, the Washington Mystics.

[14] She was brought in to back up All-Star point guard Diana Taurasi, and coach Sandy Brondello, who worked with Harding while she was with the Sparks, felt that she fit the position.

Following the team's elimination by the Minnesota Lynx, Harding announced her retirement from the WNBA after playing 9 seasons in the league.

[20][21][22] Harding was twice part of the long list for the United States women's national basketball team, but missed out on both the 2010 FIBA World Championship in the Czech Republic, and the 2012 Summer Olympics in London.

[23][24] In 2015, Harding was invited to play for the Belarus women's national basketball team, who needed more point guards.

[25] She was approved to the EuroBasket Women 2015 roster after getting a Belarusian passport,[26] and helped the team finish the tournament in fourth.

[32][33] In 2021, Harding was named the inaugural head coach of the South Sudan women's national basketball team.