[3] Two species are known: M. rudnerae from the Early Jurassic of Lesotho and South Africa, and M. chenali from the Late Triassic of France.

[2] The type species M. rudnerae was first discovered in 1966 in the Elliot Formation of Lesotho, southern Africa, by palaeontologist and archaeologist Ione Rudner.

[1] The generic name Megazostrodon means, literally, 'large girdle tooth' (from the Greek mega-large, zostros-girdle and don-tooth—referring to the large external cingula of the upper molars).

Megazostrodon is the best-known genus of the family Megazostrodontidae, part of the larger group Morganucodonta.

[9] Their skeletons changed so that their limbs were more mobile, being less laterally splayed,[10] and allowing faster forward motion.

The other bones which once made up the jaw had reduced, and in later mammals would become incorporated into the middle ear,[3] enhancing their hearing.