She has also played for three teams in the Women's Professional Soccer (WPS) league, for Tyresö FF in Sweden's Damallsvenskan and for the Houston Dash in the NWSL.

In 2005, she helped lead Pine-Richland to the Pennsylvania state high school championship and was an NSCAA All-America selection.

[4] Klingenberg claims she enhanced her soccer skills by practicing Taekwondo, and that the martial art made her a more aggressive player.

[5] Klingenberg attended the University of North Carolina at Chapel Hill and was a four-year starter for the Tar Heels.

[4] She also spent time at Western New York Flash where she won the 2012 Women's Premier Soccer League Elite.

[8] After the WPS folded, the National Women's Soccer League was created with support from the US, Canada, and Mexico.

On January 10, 2014, it was announced that the Houston Dash had selected Klingenberg with the sixth pick in the 2014 NWSL Expansion Draft.

[17][18] In March 2013, she was named to the senior team roster by US WNT coach, Tom Sermanni for upcoming exhibition matches against Germany and the Netherlands.

[19] Klingenberg made her debut for senior team on January 23, 2011, at the Four Nations Tournament against Canada, coming in as a substitute at seventy-eighth minute.

Despite seeing extensive playing time during the 2016 Summer Olympics, Klingenberg would receive sparse minutes throughout 2017 and has not been called up since January 2018.

[6] In 2019, Klingenberg, along with United States teammates Tobin Heath, Christen Press and Megan Rapinoe started Re-inc, a gender-neutral lifestyle brand.