[3][4] The Mehran Highway is a high volume traffic road, as it connects Nawabshah and Khairpur districts and offers a shortcut to and from Sukkur.

Due to those heavy vehicles and commuter buses and coaches passing through Mehran highway many deadly accidents have taken place in the past few years.

[10] On 25 March 2015, a Karachi-bound coach from Sadiqabad collided head-on with a Punjab-bound truck near Sui-Gas bus stop on the highway, resulting in the death of at least 16 people and injury of 20.

[11] On 6 July 2018, at least 15 people were killed and 25 injured when a Punjab-bound coach from Karachi, a van and a car collided near Daur town.

[12] In another tragic incident, six people including five schoolchildren were crushed to death by a passenger van, on 29 March 2021, near Kot Lalu.