[3][4] It was established in 1963 in direct response to industrialization as Sind University Engineering College, in Jamshoro about 15 km (9.3 mi) from Hyderabad.

[5] The first batch of MUET was inducted in January 1974 with the enrollment of 450 students in civil, mechanical, electrical, electronics, metallurgy, chemical, and industrial engineering.

Some students acquired private houses in the Society area in Nawabshah, where they lived for two years until newly constructed hostel blocks were made available adjacent to the college campus.

The total number of students enrolled to the First Year classes of all disciplines at Jamshoro campus under the regular scheme was 1053, with 1000 candidates from Sindh Province.

Inaugurated in 1978, postgraduate courses were started at Mehran University of Engineering and Technology, leading to a master's degree.

The university offers undergraduate, post-graduate, and doctoral studies in engineering, business and industrial management, humanities, philosophy, fine arts and science.

The USPCASW – U.S.-Pakistan Center for Advanced Studies in Water, was established at the Mehran University of Engineering and Technology (MUET) Jamshoro, with the financial support of United States Agency for International Development (USAID) Pakistan under the Cooperative Agreement signed with USAID on December 12, 2014, for five years.

[8][9] The University of Utah (UU), USA was providing technical assistance to MUET for advancing the development and growth of USPCAS-W.[10] The tangible deliverables of the Center include postgraduate degree programs, applied policy research, facilitation of public-private partnerships, and provision of policy advice in a range of water-related disciplines.

Later in 2014, the Federal College of Art and Design (FCAD) was converted into the Centre of Excellence in Art & Design (CEAD) by the Ministry of Education, Government of Pakistan Islamabad, and the project was handed over to the Mehran University of Engineering and Technology, Jamshoro as its academic part.

Programs of IEC are designed to appeal to everyone from students, staff, industry, who are just trying to obtain a primer on entrepreneurship, to serial entrepreneurs.

SO(C-IV) SGA&CD/4-29/09 dated 2 April 2009 constituted a High Power Board of Directors, established a constituent, and upgraded it from college to campus and renamed as Mehran University of Engineering and Technology Shaheed Zulfiqar Ali Bhutto Campus.

The campus is headed by Pro-VC who will work under the administrative control of Mehran University of Engineering and Technology, Jamshoro.

[26] In 2024, Government of Sindh has announced to open a Rana Chandar Singh MUET campus of Mehran University of Engineering and Technology at Umerkot district.

In 2022, Government of Sindh has announced to open a campus of Mehran University of Engineering and Technology at Sujawal district.

[27] MUET has decided to establish a sub-campus at Jacobabad to cater to the needs of engineering students of northern Sindh.

The Pre-admission Test of the candidates is conducted by the agency prescribed by Mehran University of Engineering and Technology, Jamshoro.

[36] On April 28, an independent audit by a team of International Organization for Standardization 9001:2008 found glaring omissions in the MUET examination controller's department.