[2] At 16, she was inspired to pursue acting by artistic director Kumiko Mendl of the New Earth Theatre, of which Mac is now an associate.
[4] Studio Ghibli head and director of the original movie Hayao Miyazaki said of Mac's performance: "I've never imagined San as a real-life human being, but if she did exist, it would be you.
"[1] In August 2022, it was announced Mac would play the lead role of Mei in the Royal Shakespeare Company's staging of another Studio Ghibli movie, My Neighbour Totoro.
[8] In May 2023 Mac appeared as Juliet, alongside Ncuti Gatwa's Romeo, as part of the Coronation Concert[9] and starred in Kimber Lee's untitled f*ck m*ss s**gon play, in the Royal Exchange, Manchester and Young Vic in London.
[10] Mac has appeared in the long-running BBC drama Call the Midwife,[11] and in the Comedy Central sketch show East Mode.