[1] She made her acting debut in the 2009 action-adventure film Hard Revenge Milly: Bloody Battle as a minor character.

[1] Her first lead role came in the 2016 teen drama Koe Koi as Yuiko Yoshioka, a high school student who meets a mysterious boy who wears a paper bag over his head.

[5] Later that year she provided the voice for the character Zaya in the Japanese version of the film Gods of Egypt.

[6] She also appeared in commercials for Calpis Water,[7] Sekisui House,[8] Townwork,[9] UQ Mobile,[10] and Alpen.

[12][13] For her lead role in this asadora, Nagano was named the Best Actress at the 98th Japan Television Drama Academy Awards.