At the age of seventeen Meïr was called to the rabbinate of Fulda, where he had charge also of a number of pupils.
He enters at once upon the discussion of his subjects, which he treats in detail though without digression; nor does he attempt to derive his proofs from remote Talmudic passages.
On his death-bed Schiff is said to have called his daughter Henlah and told her to keep all his works in a box until one of his younger relatives should be able to study and publish them.
Henlah sent the box containing the works to a strange house, where they became moth-eaten, and some of them were stolen; so that her son, Michael Stein, came into possession of only a remnant of them, which he finally published, probably in 1737, at Homburgvor-der-Höhe under the title Ḥiddushe Halakot.
Most of Schiff's notes on the four Ṭurim, as well as his cabalistic works and Talmudic decisions, were destroyed during the conflagration at Frankfort-on-the-Main in 1711.