[1][2] Meithalun has four mosques, six schools, four pharmacies, two weather stations, two kindergartens, two clinics: maternity and general, several workshops, two multipurpose halls, two cemeteries, a police station, an office of the Ministry of Interior of the State of Palestine, three bakeries, four Internet cafes, two cultural centers, two major diwans, and a bank (Bank of Palestine).

According to E. H. Palmer, Meithalun's name derives from Mithilihieh, which in Phoenician means "image"; the classical Arabic translation would relate to "traces of a dwelling which are becoming effaced".

They paid a fixed tax-rate of 33.3% on agricultural products, including wheat, barley, summer crops, olive trees, goats and beehives, in addition to occasional revenues; a total of 7,160 akçe.

[6] During the later Ottoman era, Meithalun was part of the Mashariq Jarrar subdistrict and in the 19th century was in the zone of influence of the Nablus-based textile merchant Hajj Isma'il Arafat, along with the villages of Sanur, Beit Lid, Silat ad-Dhahr and Jaba'.

[7] In 1838, Biblical scholar Edward Robinson saw the village when he travelled in the region, and described it as being situated in an extremely fertile area.

"[11] In 1882, the PEF's Survey of Western Palestine described it as “a village of moderate size, of stones and adobe, with a well to the north, situated at the foot of a high hill, with a few olives in the plain”.

[13][14] Meithalun's two main clans, the Na'irat and the Ruba'iya, participated in the countrywide 1936–1939 revolt against British rule and increased Zionist settlement in Palestine.

[21] In the 2005 municipal elections, Fatah won the largest number of seats (five), followed by the Popular Front for the Liberation of Palestine (four) and Hamas (three).

[24] The nearest localities to Meithalun are Sanur to the west, Siris and Judeida to the southeast, Aqqaba to the east, Sir and Zababdeh to the northeast, and Misilyah to the north.

The tell has an elevation of 423 meters above sea level and consists of ruins, namely the remains of a walled city, building foundations, a tomb and water tanks cut from stone.