The Arid Zone Agricultural College was established at the University of Asmara but was then moved to Agarfa in southern Ethiopia in 1990.

In 1993, the Arid Zone Agricultural College was moved to Mekelle and started with 42 students in 3 degree programs.

Also, the Faculty of Law started its operation by accepting diploma students through a continuing education program.

In 1895, a fort was established on the small hill overlooking the campus, and the place served as a military stronghold, that was conquered by the Italian army in 1935.

[5] After the Italian defeat in 1941, the Ethiopian army took over the place, which expanded it into a large military camp.