[3] It was for a long time only known from the type series collected in 1960 (the precise location of which was unknown), until another population was discovered in 2004.

Later on, palmar and plantar surfaces and the posterior region of venter show a pallid orange colour that gets more intense over time.

There are small white spots covering all ventral surface, including limbs, throat, pectoral and abdominal regions.

[3] Melanophryniscus macrogranulosus is an explosive breeder, breeding after heavy rains in temporary streams.

Males call in shallow water along the streams both day and night, sometimes hidden in small cavities in the ground.

[1] Caorsi and her colleagues suggest that it should be classified as "Endangered" because of its small range, fragmented habitat, and disturbance from human activities.