[18] Melco International's Mocha Clubs, opened in 2003,[8] helped introduce "cafe-style slot-machine parlors" to Macau, which were uncommon at the time.

[19] Melco International formed a joint venture with Publishing and Broadcasting Limited (PBL), an Australian casino operator,[8] in November 2004.

[20][6] With Lawrence Ho and PBL's chief executive James Packer appointed co-chairmen,[21] the venture was breaking ground on a new casino project in Macau by December 2004.

[22][23] With Melco International retaining a third of the shares,[11][21] the initial public offering raised US$1.14 billion and ranked as the year's fourth-largest IPO in the United States.

[5] Melco International was a founding signatory of the Hong Kong Corporate Governance Charter.

[26] With Lawrence Ho as chairman and chief executive,[8] in October 2018 Melco Resorts filed with the U.S. Securities and Exchange Commission[28] for a spin-off and NYSE listing of its Studio City International Holdings Limited unit.

[5] Melco Resorts operates several subsidiaries in localized markets such as Cotai,[28] Macau,[5] and the Philippines.

[6] The following year, City of Dreams Macau's House of Dancing Water attraction became "the most popular" show in Macao.

[5] On December 7, 2011, Melco Crown was listed on the Hong Kong Stock Exchange's main board.

The following year, Melco Crown acquired a majority share of Manchester International Holdings Unlimited Corporation, which was listed on the Philippine Stock Exchange.

[39] In 2015, Melco Crown opened its $3.2 billion Studio City Macau resort[11][10] after acquiring a 60% interest in the Hollywood-themed development in 2011.

[41] In 2018 Melco Resorts opened Morpheus, a $1.1 billion hotel tower designed by Zaha Hadid, at City of Dreams Macau.