In February 2003, Melendi released his first solo disc called "Sin noticias de Holanda", with twelve songs.

However, he reached true fame with the 2004 Vuelta a España chose his song "Con la luna llena" as its official theme.

He also wrote the song "Gangs of London" for the occasion, going on to film a video amidst police lights and sirens.

The videogame was launched on 1 August of that year in the UK and on 6 September in Spain; EMI stepped in to distribute his CDs worldwide.

He also did an advertising campaign for Canal+ Spain entitled "Me gusta el fútbol" (I Like Football), for which he wrote a song of the same name.

Currently, Melendi directs his Blue Donkey Music company, helping young singers start their careers.

He's offered contracts to four groups, Algunos Hombres Buenos, Rasel, La Dama y Belo, and Los Susodichos.

On 17 December 2009, he released a new double CD, Aún más curiosa la cara de tu padre, including the original disc and another with nine new songs and links to exclusive content on his website.

In 2011, he recorded a cover of "True colours" by Cyndi Lauper in Catalan called "Ulls dolços", for the CD of TV3's telethon La Marató.

The other songs released were "La Casa No Es Igual", "Destino o Casualidad" and "Yo Me Veo Contigo".

On 2 June 2017, he released remix version of "Destino o Casualidad" with American duo Ha*Ash, along with the music video.