[1] She is known for her work on meiosis in mammalian oocytes,[2] for her studies on the mechanisms leading to the age-related decline in female fertility,[3] and for the development of the Trim-Away protein depletion method.

[5] In 2004, she received her diploma in biochemistry from the University of Bayreuth, Germany, where she studied the incorporation of Cenp-A into centromeres in Drosophila embryos with Stefan Heidmann and Christian Lehner.

[6] Melina Schuh did her PhD with Jan Ellenberg at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, where she established methods for high-resolution imaging of meiosis in live mouse oocytes.

[13] In addition, her group developed a strategy to perform high-content RNAi screens for meiotic genes in mouse oocytes.

She found that human oocytes have a surprisingly slow and error-prone mechanism for assembling the meiotic spindle,[15] increasing the likelihood of segregation errors.