[2] She made her television debut in the episode of NBC legal drama Law & Order in 1997, and as of 2003 began playing regular guest-star roles in shows like Star Trek: Enterprise, Nip/Tuck, Ghost Whisperer, Criminal Minds, The Closer, Castle, NCIS, Modern Family and True Blood.
Her memorable 2003 Star Trek: Enterprise role of Feezal, the alien scientist and second wife of Doctor Phlox, explored the concept of polyamory.
On television, she had recurring roles in the ABC comedy-drama series Desperate Housewives as Sister Mary Bernard, a nun pursuing a married man; and on the AMC period drama Mad Men, as Anna Draper, polio survivor and widow of the man whose identity Don Draper stole in Korea.
In 2013, Hamilton appeared as Odessa Burakov in the first two seasons of the Lifetime comedy-drama series Devious Maids,[1][4] for which she perfected a Russian accent.
[2] In 2015, she had recurring roles in the USA Network series Dig,[5] and the SundanceTV drama, Rectify.