Created and co-written by Davhi Waller and directed by Anna Boden and Ryan Fleck, Amma Asante, Laure de Clermont-Tonnerre, and Janicza Bravo, the series details the unsuccessful political movement to pass the Equal Rights Amendment and the efforts of conservative activist Phyllis Schlafly in the 1970s.

It features a large ensemble cast led by Cate Blanchett, Rose Byrne, Uzo Aduba, Elizabeth Banks, Margo Martindale, John Slattery, Tracey Ullman, and Sarah Paulson.

Through the eyes of the women of that era – both Schlafly and prominent second-wave feminists including Gloria Steinem, Betty Friedan, Shirley Chisholm, Bella Abzug, and Jill Ruckelshaus – the series explores how one of the toughest battlegrounds in the culture wars of the 1970s helped give rise to the Moral Majority and permanently shifted the American political landscape.

[3] Mrs. America was created and co-written by Emmy Award winning Canadian writer Dahvi Waller, who previously had writing credits on acclaimed television shows such as Mad Men and Halt and Catch Fire.

The head of FX, John Landgraf, had become interested in the reappraisal of historical events "embedded in America’s collective consciousness" after Ryan Murphy originally sketched out the plot of American Crime Story.

[8] The nine-episode miniseries was written by Dahvi Waller, Tanya Barfield, Boo Killebrew, Micah Schraft, April Shih, Sharon Hoffman, and Joshua Allen Griffith and directed by Anna Boden and Ryan Fleck, Amma Asante, Laure de Clermont-Tonnerre, and Janicza Bravo.

[14] In May 2019, Uzo Aduba, Rose Byrne, Kayli Carter, Ari Graynor, Melanie Lynskey, James Marsden, Margo Martindale, Sarah Paulson, John Slattery, Jeanne Tripplehorn and Tracey Ullman were added to the series.

[30] James Poniewozik, writing for The New York Times, praised the series, calling it "breathtaking" and "a meticulously created and observed mural that finds the germ of contemporary America in the striving of righteously mad women."

Berman also praised the show's writers, stating "This degree of moral, political and philosophical complexity is what differentiates Mrs. America from so many other recent dramatizations of women’s movements past".

[32] Inkoo Kang, writing for The Hollywood Reporter, called the series "a tremendously executed balancing act" and stated that "there's no denying that Mrs. America makes history come alive, in thoughtful and achingly real detail", whilst also praising the performances of the central cast.

They argued the series portrayed the fight for the ERA as a catfight between women instead of showing that lobbyists protecting the financial interests of insurance and other companies affected by the change were far more influential in preventing the law from being passed.

[34][35] Steinem and Smeal's comments were later disagreed with by fellow second-wave feminist Brenda Feigen, who called the series "extraordinary" and stated that, in her view, the nuance of the characters were portrayed very accurately.