Melipilla Province (Spanish: Provincia de Melipilla) is one of six provinces in the Santiago Metropolitan Region of central Chile.

As a province, Melipilla is a second-level administrative division of Chile, governed by a provincial delegate who is appointed by the president.

The current delegate is Sandra Saavedra, who was appointed by president Gabriel Boric.

The province comprises five communes (Spanish: comunas), each governed by a municipality consisting of an alcalde and municipal council: The province spans an area of 4,065.7 square kilometres (4,066 km2), the second largest in the Santiago Metropolitan Region.

At that time, there were 80,790 people living in urban areas, 60,375 living in rural areas, 71,595 men, and 69,570 women.