[1] She had a sister Sibylla of Lusignan, a younger brother, Amalric who died as a young child.
By her mother's previous marriages, Melisende had three half-sisters, Maria of Montferrat, who succeeded their mother as queen of Jerusalem on 5 April 1205; Alice of Champagne, and Philippa of Champagne.
In January 1218, Melisande married Prince Bohemond IV of Antioch.
[1] The marriage produced three daughters: Melisende protested the succession of her nephew King Henry I of Cyprus as regent of Jerusalem on the death of her half-sister Alice in 1246.
Upon the childless death of her only surviving daughter, Marie sometime after December 1307, the line of Melisende became extinct.