She served as associate priest at Trinity Church, New York City from 1993 to 1994; associate priest at St Andrew's Church in Trenton, New Jersey between 1994 and 1996; vice president for administration at the General Theological Seminary from 1993 to 1997; vice president of Brand and Systems Development at Tom's of Maine from 1997 until 2001; congregational development consultant for the Diocese of Maine between 2002 and 2004; and rector of Trinity Church in Castine, Maine from 2002 to 2005.

On November 30, 2013, Skelton was elected the 9th Bishop of the Anglican Diocese of New Westminster: it was on the third ballot and by a substantial majority at an electoral synod held at Christ Church Cathedral, Vancouver, British Columbia, Canada.

Skelton was the first woman, the first American and the first person to have had a career outside of the church prior to ordination to be Bishop of the Diocese of New Westminster.

[4] On May 12, 2018, she was elected Metropolitan of the Ecclesiastical Province of British Columbia and Yukon, an office that comes with the title archbishop.

Skelton was installed as Metropolitan on Holy Cross Day, September 14, 2018, during a celebration of the Eucharist prior to the opening of Provincial Synod in Sorrento, British Columbia.

[6] Skelton married Seattle-based family counsellor Eric Stroo on August 15, 2015, in Cannon Beach, Oregon.