She supports female screenwriters through the WGA Diversity Committee and co-founded the League of Hollywood Women Writers.

From 2006 to 2009, she served as the head writer of the Showtime series Dexter, rising to executive producer by the time she departed at the end of the fourth season.

[2] She attended a "massive public high school with a crowd of people bunched in a classroom and expected to learn" in Southern California.

She says she began too late, however, so she moved to Los Angeles, California to pursue a career in the film industry instead.

[1][6] Rosenberg's first project was a dance film commissioned by Paramount Pictures that was ultimately never made.

She first wrote for Class of '96 in 1993, and went on to work on shows including Dr. Quinn, Medicine Woman (1995–1996), Dark Skies (1996), The Magnificent Seven (1998), Ally McBeal (2001) and Birds of Prey (2002) before she came to join the writing staff of The O.C.

She and the other members of the Dexter writing staff were nominated for a Writers Guild of America Award for best Dramatic Series at the February 2008 ceremony for their work on the first season.

She was nominated for the WGA award a third consecutive time at the February 2010 ceremony for her work on the fourth season of Dexter.

[14] Summit Entertainment, the production company which had produced Step Up,[15] offered Rosenberg the chance to adapt Stephenie Meyer's bestselling novel Twilight into a film of the same name, which she accepted.

[15] She wrote a detailed 25-page outline in August 2007, expecting to have another two months to write the actual screenplay, but had only five weeks to finish the script before the commencement of the 2007–2008 Writers Guild of America strike.

[21] Rosenberg was on the Writers Guild of America's board of directors for five years before stepping back because "you can get really, really wrapped up in it".

[18] She is currently involved in the WGA Diversity Committee supporting female screenwriters, but is more active in the League of Hollywood Women Writers, which she and several other women set up while on strike, aiming to fight the "boys' club mentality" in television writing rooms.

[27] In August 2018, it was reported that Rosenberg had signed a deal with Warner Bros. Television and would leave Jessica Jones after season 3.