Melody became famous at the age of 10 with her song "El baile del gorila", one of the biggest summer hits of 2001 in Spain.

[6] Melody was discovered by rumba flamenca veteran and producer El Fary[5][8] after her father sent him a demo tape of her singing.

[10] The lead single "El baile del gorila", which was written and composed by José Antonio Benítez Serrano,[11] became a big summer hit in Spain.

The soundtrack album, which also includes tracks by Jon Secada, Gloria Estefan, Huey Dunbar, and other well-known Spanish-language artists, went on sale on 23 March 2004.

The song, titled "Cu'mme", was part of Frangoulis' second international album Follow Your Heart, which was released on 9 November 2004, on Sony Classical.

[34][35][36][37] By 2005 Melody had disappeared from the media and waited three years to release another record, dedicating that time to her personal development.

[43] At the end of 2008, Melody collaborated with Los Vivancos,[2] a flamenco dance group,[45][46] on a song titled "Amante de la luna",[2] which was written by Manolo Carrasco and Fernando Bermúdez.

[47] Melody and Los Vivancos entered the Spanish national pre-selection for the Eurovision Song Contest 2009, to be held in Moscow.

[53][54][55] In 2012, Melody gave a preview of her sixth studio album, releasing a single titled "Ten cuidaíto conmigo".

[59] On 25 February 2013, Melody appeared on Antena 3 in a special charity episode of Tu cara me suena, a show in which celebrities impersonate famous singers.

[60] On 8 March 2013, Melody released a merengue version of her song "No sé", which she re-recorded as a duet with Venezuelan reggaeton artist DJ Pana.

[63] From October 2013[64] to March 2014, Melody competed in the third season of Tu cara me suena, reaching the final along with Edurne, Xuso Jones, Llum Barrera, and Florentino Fernández; where she finished second.

[65][2] During the season, she impersonated artists like Bonnie Tyler, Katy Perry, Ricky Martin, Gloria Gaynor, Cher, Gwen Stefani (No Doubt), Alesha Dixon, and Lady Gaga.

[67][76] The album's fourth single "Hoy me voy"[77] was launched on the radio stations Radiolé and CafeOlé on 3 June 2014.

[78] On 23 December 2014, Melody premiered a music video for the album's second single "Mucho camino por andar".

[80][81] In addition to her solo career, Melody has formed a musical duo named Melek 2 with her brother Eleazar (Ele).

[82][83][84] "Tú lo sabes" peaked at number 24 on the Canal Fiesta Radio [es] chart in October 2015.

[92][93] The music video was directed by Pedro Vázquez and Descemer Bueno and was filmed in March 2017 during Melody's visit to Cuba at locations in Havana including Jardines de La Tropical.

[94] On 30 January, Melody performed last in the second Semi-Final and advanced to the Final after finishing in the top half of the jury and public votes.