When disturbed the adult releases oily droplets of hemolymph from its body to repel potential predators, which may cause blistering on human skin.

Legs each have an outer metathoracic tibial spur with apical portion produced anteriorly.

[5] The moderate to dense punctation on the head and pronotun, and the presence of a conically produced scutellum readily distinguishes M. angusticollis from the other Meloe species.

[6] Blister beetles undergo complete metamorphosis, which includes egg, larva, pupa, and adult stages.

[7] This species is active primarily during spring and early summer across the northern half of the United States and southern Canada.