Two of his touchdowns came against Georgia in a 45–42 victory in Athens, which included a 68-yard run during a fake punt and a 5-yard fumble return.

[1][2] Ingram's strong senior campaign helped propel the Gamecocks defense to a final #4 national poll ranking, and he was a first-team All-Southeastern Conference (SEC) selection, and was recognized as a consensus All-American.

On May 14, 2013, Ingram tore his anterior cruciate ligament during the Chargers' organized team activities and was expected to miss the entire 2013 season.

In Week 16, Ingram sacked Oakland Raiders quarterback Matt McGloin while forcing a fumble.

In the wild card game against the Cincinnati Bengals, Ingram picked off quarterback Andy Dalton for his first postseason interception.

On October 4, 2015, Ingram strip-sacked Cleveland Browns quarterback Josh McCown and recovered the fumble.

[12][13] Ingram earned the AFC Defensive Player of the Month for September 2017 after recording 5.5 sacks, including a three-sack game against the Chiefs in Week 3.

[15] Prior to the start of the 2018 NFL season, Ingram predicted that the Chargers would win Super Bowl LIII and he said that "We're ready.

[22] Ingram was traded to the Kansas City Chiefs on November 2, 2021, in exchange for a sixth-round selection in the 2022 NFL draft.