[7] Quarterback prospect Andrew Luck received signifigant attention in the weeks preceding the draft.

On April 17, Indianapolis general manager Ryan Grigson announced that the team would take Luck as their first-overall pick after releasing their longtime starting quarterback Peyton Manning, saying it was "the right thing to do" in anticipation of the "media gauntlet" Luck would face in the days leading up to the draft.

[9][10] As a result, he had been the subject of the "Suck for Luck" campaigns by fans, who hoped that their teams would end up with the worst record in the 2011 season so they would have the chance to draft him.

[11][12] He was successful with the Colts, but dealt with several injuries throughout his career and decided to retire in 2019 while still in his prime, after winning the NFL Comeback Player of the Year Award.

[13] Heisman Trophy-winning quarterback Robert Griffin III was the subject of another major story in the draft.

[14][15] The draft was highly regarded for its quarterback talent, with six out of the eleven quarterbacks selected (Luck, Griffin III, Ryan Tannehill, Russell Wilson, Nick Foles, and Kirk Cousins) selected to at least one Pro Bowl.

[20][21] Besides its quarterbacks, the draft overall is considered one of the best of all-time with numerous prospects showing Hall of Fame talent throughout their careers, including Defensive Player of the Year winners Luke Kuechly and Stephon Gilmore, along with perennial Pro Bowlers Lavonte David, Bobby Wagner, Fletcher Cox, T. Y. Hilton, Chandler Jones, Johnny Hekker, and Justin Tucker.