It is the largest health system in Central Massachusetts, and is the clinical partner of the UMass Chan Medical School.

[7] The largest of these is the University Campus, which is a 640-bed tertiary, research and academic medical center located in Worcester, servicing central Massachusetts.

The merger was a result of higher insurance costs and the system has increased hospital revenue and amount of patient beds.

UMass Medical Center has operated LifeFlight, New England's first hospital-based air ambulance, for over 30 years.

[16][17] In late February 2020, hospital authorities disclosed that they had a patient under quarantine at UMass Memorial Medical Center after traveling to China.

[20][21] The UMass Memorial Health Children's Medical Center is a pediatric acute care hospital located in Worcester, Massachusetts.

UMass Memorial Health - HealthAlliance-Clinton Hospital has campuses in Clinton, Leominster and Fitchburg, MA.

In response to this criticism and challenges, UMMHC underwent significant restructuring towards a more lean business model.

A number of employee positions (reportedly over 500), predominantly in non-patient contact areas, were also eliminated in an effort to improve system efficiency.

[41] In December 2013, UMMHC announced its intent to transfer ownership of Wing Memorial hospital to Baystate Health in Springfield, MA.

Following the above changes, along with an effort to standardize clinical and business processes, the system reported a stabilization of its financial position in 2014.