Five contestants, all women and one of them a returning champion (or designate), competed and were spotted $50 at the start of the game.
The winner at the end of the show won a $1,000 bonus and returned the next day to meet new challengers.
Three weeks after this show's cancellation, NBC moved Garagiola to another daytime game, Sale of the Century, which he hosted for the rest of its original run.
Three on a Match, hosted by Bill Cullen, replaced Memory Game on the NBC schedule.
According to The Encyclopedia of Daytime Television by Wesley Hyatt, Griffin did not identify his production company on the end credits of the program.