In March 1996, he joined Dr. Shuo Lin’s lab as visiting scholar and started to work on zebrafish embryonic development[6][7][8] at the Institute of Molecular Medicine and Genetics, Medical College of Georgia, USA.

In the mid to late 1990s, he and colleagues demonstrated for the first time the utility and efficiency of the GFP reporter for dissecting regulatory elements of genes in living organisms.

Meng Anming and his coworkers discovered that a novel maternally expressed Huluwa, which encodes a transmembrane protein, activates β-catenin signaling for embryonic organizer and body axis formation in the zebrafish and frog by promoting Axin degradation.

Recently, Meng Anming’s lab disclosed the clock-like function of nuclear pore complex maturation for the onset of zygotic genome activation in zebrafish embryos.

[52] Besides, his lab discovered for the first time an indispensable role of the second polar body in setting up the initial cell fate asymmetry during pre-implantation period and in regulating post-implantation development in mouse embryos.