First, it flows east in the direction to Maloja Pass, then turns west through the Val Bregaglia (German: Bergell) and crosses the border to Italy in Castasegna (Dogana).

It is joined by the Acquafraggia close to Piuro, and then turns south at Chiavenna, just before it receives the river Liro from the right at Prata Camportaccio.

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