The CLE has a rounded, single-bar grille with a honeycomb mesh insert and is accompanied by C-Class-style headlights and sporty air intakes.

[7] It also features the latest iteration of the Mercedes-Benz User Experience (MBUX) system, which is also seen on multiple other models.

[15] The engine options of the CLE are shared its saloon counterpart, the W214 E-Class, all of which feature the 48-volt EQ-boost mild hybrid system.

[7] The model features a mild-hybrid AMG-enhanced M256 3.0-liter inline six-cylinder engine with exhaust gas turbocharger and electric auxiliary compressor, standard AMG Performance 4MATIC+ fully variable all-wheel drive and active rear-axle steering, and styling with distinctive AMG design elements and flared wheel arches.

The 48-volt integrated starter generator (ISG) provides support at lower engine speeds with 23 hp and 151 lb-ft.[19] A Mercedes-AMG CLE 63 model is planned for 2025.