[8] The W223 directs heat from the engine to the wheel arches and underbody to improve airflow and has a drag coefficient of 0.22.

[9] At the launch, Mercedes-Benz announced that its V12 engine would be exclusive to Mercedes-Maybach S 680 4MATIC and that no coupé or convertible version of S-Class would be produced.

[12] The MBUX system features over-the-air software update support, automatic driver profile selection via voice or fingerprint recognition, and a virtual assistant which activates by saying "Hey Mercedes".

[17] The car features 22 cameras and radar sensors for the adaptive cruise control, automatic steering, lane departure warning, emergency braking, and traffic sign recognition.

Radar sensors can predict oncoming side collisions and raise the suspension by 8 cm (3.1 in) to direct the crash force towards the doorsills.

[19] Optional equipment includes rear-axle steering, rear-seat airbags, and a head-up-display with augmented reality for navigation directions.

[22] The 4Matic AWD system used on non-AMG models uses Magna Trumax transfer case with an open double-planetary type center differential.

This system replaces the open center differential with an electronically controlled multi-disc clutch which enables stepless coupling of the front axle to the drivetrain.

[23] The models with six-cylinder inline petrol engines have a 48-volt electrical system with an integrated motor-generator to provide additional power when needed.

[33][34] The Mercedes-Maybach S 580 e debuted in February 2023 as the brand's first plug-in hybrid model, featuring an inline-six engine and an electric motor that produce a combined 510 PS (375 kW; 503 hp) output.

[38] The car features a two-tone paint job consisting of Nautical Blue and Rose Gold above and below the belt line, respectively.

[39] The MBUX system was upgraded with the intention to emphasize the atmosphere of a fashion show catwalk, with sparkling glitter clouds and a variety of rose gold accents.

Drivers are greeted with sparkling particles and a magnolia blossom on the profile selection menu, and available are 12 different elegantly dressed avatars, such as in a tailcoat, evening gown, and dinner jacket, and are adorned with fine accessories.

[40] The Haute Voiture is accompanied by a special hand-made gift box containing a key ring, its badge number, and a scale model.

The bag collection has been released in early 2023 in limited run and are available at both Maybach Icons of Luxury physical and online stores.

Alicia Keys was the first person to receive an S-Klasse „Maybach by Virgil Abloh” S 680, as a gift from her husband Swizz Beatz.

The interior has sand-colored Nappa leather accented by black trim on the doors, center console, and steering wheel.

It uses a plug-in hybrid drivetrain, which is powered by a 4.0 L twin-turbo V8 in the form of the M177, along with an electric motor and 13.1 kWh battery pack.

In certain markets such as United States, China, Russia, and Turkey, the S-Class are sold in long wheelbase version only.