The original model was a four-door sedan based on the Mercedes E-Class platform, marketed as a four door coupé.

[6] It primarily competes with other fastback sedans like the BMW 8 Series Gran Coupe, Porsche Panamera and Audi A7.

[9] The C219 CLS is based on the W211 E-Class platform, and shares major components including the engines, transmissions, and has an identical wheelbase of 2,854 mm (112 in).

[17] The Shooting Brake body style was in development for the C257 CLS, but was shortly discontinued due to poor and declining demand overseas for the last generation model.

[19] The latter equips the CLS 53 AMG with features such as a mild hybrid system and an Panamericana radiator grille, which pays tribute to 300 SL model.