[14] The Mercedes-AMG EQS 53 4Matic+ was presented at the Munich Motor Show in September 2021 and is the first all-electric AMG car.

[15] A luxury car, the EQS comes with rear-wheel steering, over-the-air updates, wireless phone charging, 360-degree camera system, keyless entry, and can optionally be equipped with seats with massage, head-up display with augmented reality, automatically opening and closing doors, integrated toll payment system, gesture controls, HEPA air filter, heat, noise, and infrared rays insulated glass and heated windshield.

[16] The high-end versions of Mercedes-Benz EQS feature two separate OLED screens and an LCD instrument cluster that covers nearly the full extension of the dashboard.

[19] The car has several safety and automated features, including adaptive cruise control, lane centering, automatic lane changing, automated emergency braking, avoidance assist (for pedestrians and bicycles), blind spot monitoring including rear seat exit warning, cross-traffic alert, traffic-sign recognition, automatic parking assist, and adaptive headlights.

[30] Changes includes the addition of a free-standing hood ornament, an updated front fascia with a faux grille and horizontal chrome slats, the interior received minor changes with chrome accents on the B-pillar air vents and the rear seat pillows features contrast stitching and Nappa leather piping, and increased battery capacity for model variants.

In December 2022, Bloomberg News listed the EQS as a "terrific" (great) alternative option to the Tesla Model S for auto owners angered by Elon Musk.