[6] The new vehicle, developed in conjunction with the Renault-Nissan-Mitsubishi Alliance, was to be assembled at Nissan and Renault plants in Europe and South America.

[7] Plans to produce the pickup at the Renault plant in Santa Isabel, Argentina were cancelled due to alleged contractual disputes between executives from both marques.

[8] According to Mercedes, the X-Class would be the world's first true "premium" pick-up truck, although it followed the failed Lincoln Blackwood and Lincoln Mark LT, two upmarket versions of the Ford F-150, along with the also-failed Cadillac Escalade EXT, a pickup variant of the full-size luxury SUV and an upmarket version of the Chevrolet Avalanche.

Despite the X350 sharing the same V6 diesel engine platform as the G-Class and other Mercedes models, public perception was that the X-Class was an expensive rebrand of a Nissan Navara, an image it struggled to shake throughout its short production run.

[13] On 19 July 2017, the promotional video/advertising spot "Mercedes-Benz X-Class: Pickup Meets Lifestyle – Trailer" was released, with "We Are Young" song by Blues Saraceno as soundtrack.