The series starred McCambridge, George Brent, and Dane Clark as reporters for the fictional Trans Globe Wire Service.

When, according to the pact terms, certain celestial phenomena signaled it was time for the marriage, Carlotta (McCambridge) disappeared Darrin and pushed for Samantha to marry her coddled son Juke (played by veteran character actor Steve Franken).

[citation needed] In 1954, she co-starred with Joan Crawford and Sterling Hayden in the offbeat western drama, Johnny Guitar, now regarded as a cult classic.

"[3] McCambridge played the supporting role of Luz in the George Stevens classic Giant (1956), which starred Elizabeth Taylor, Rock Hudson, and James Dean.

In 1959, McCambridge appeared opposite Katharine Hepburn, Montgomery Clift and Elizabeth Taylor in the Joseph L. Mankiewicz film adaptation of Tennessee Williams' Suddenly, Last Summer.

McCambridge appeared as a leather jacket-wearing hoodlum in Touch of Evil, reuniting with her former radio colleague Orson Welles for the 1958 film.

McCambridge provided the dubbed voice of Pazuzu, the demon possessing the young girl Regan (played by Linda Blair) in The Exorcist.

To sound as disturbing as possible, McCambridge insisted on swallowing raw eggs, chain smoking and drinking whiskey to make her voice harsh and her performance aggressive.

[11] Her dispute with Friedkin and the Warner Bros. over her exclusion ended when, with the help of the Screen Actors Guild, she was properly credited for her vocal work in the film.

She returned in 1979 for El Centre's production of The Mousetrap, in which she received top billing despite her character being murdered (by actor Jim Beaver) fewer than 15 minutes into the play.

She first served as a volunteer member of the Board of Directors, then as president and CEO, responsible for the day-to-day operations of the treatment center, which at the time was a 76-bed residential program for both male and female alcoholics.

[1] Despite never even personally coming out as either homosexual or bisexual, The Advocate stated that McCambridge "played the most fiercely dykey roles on-screen to perfection.

[3][13][14] McCambridge's son John Markle, a UCLA graduate with a Ph.D. in Economics,[1] joined the Little Rock, Arkansas, investment firm Stephens Inc. in 1979, after working for Salomon Brothers in New York City.

McCambridge refused to cooperate with Markle and the company in instituting a repayment scheme that would have kept the matter from becoming public, saying that she had done nothing wrong and that Stephens Inc. owed her money.