The game received a port to the PlayStation 2 (PS2) titled Mercury Meltdown Remix released a month after the original, with improved graphics, new levels, and optimized for the PS2's controller.

Mercury Meltdown Remix received mixed reviews in regards to the PS2 controls with some criticism of removing multiplayer.

The goal is to navigate one or more blobs of mercury to one or more finish posts in the level by tilting the stage using the analog stick of the PSP.

Players automatically lose the stage if all mercury is lost, or unable to meet the requirements to complete the level.

[1][2] The game is made up of worlds referred to as "Laboratories" that are split into 16 stages represented as test tubes.

[1][2] Mercury Meltdown introduces the Playground; a circular arena, with most of the items found in stages to play and test with.

The Cold state makes the mercury a semi-solid blob that moves slowly and is harder to split.

Metrix is a match 3 puzzle minigame requiring one to make a group of three or more colored blobs that fit inside a pre-defined grid.

In Shove, players aim the mercury for the center spot of a target, avoiding hazards; similar to curling.

Early in the production stages, Archer Maclean, who originally coined the concept of the first game, had resigned from Ignition Banbury.

[3] The first game, Mercury, was released in a tight production schedule to match the launch of the PlayStation Portable, resulting in a lack of refinements.

[3][4] Ignition Banbury chose to use a cel-shaded style to differentiate it from its predecessor and to appeal to a wider audience.

[15] Ignition Banbury further improved graphics from Mercury Meltdown Remix, added in new levels, and refined the difficulty curve.

[38] In regards to the original PSP version, critics gave praise on the improvements it made from the difficult and new visual style.

[25] IGN UK gave it an editor's choice award, although they said that the sound could be better and a lack of multiplayer is disappointing, especially on the Wii.

[28] GamePro stated the motion controls were fresh and a lot of fun, however also criticized the lack of multiplayer option.