In 1869, the first Sisters of Mercy in Louisville arrived from their community in St. Louis to run a struggling Federal Marine Hospital.

The sisters came to the United States in 1854 to establish many schools and hospitals throughout the country, starting in New York and California.

Mercy was originally built in downtown Louisville on Broadway, before it moved to the Fegenbush location in 2007.

[6] Since moving, Mercy has expanded their campus to include Evan's Park, which has their very own soccer and softball fields, as well as tennis courts, and a track.

One of the most advanced projects the Mercy Academy STEM program has taken on is Mammoth Cave National Park exploration.

The students and faculty of the STEM program spend months designing and building underwater robots to help map out the national park's aquatic floor.

Preparing for the 2021–2022 school year, Mercy Academy created a house system for all students and faculty.