[2] She appeared in both Canadian and British productions, notable starring in the BBC sketch show Man Stroke Woman (2005–07) and the comedy films Confetti (2006) and Frequently Asked Questions About Time Travel (2009).
Sam Wazowski in the CBC police comedy-drama series, Pretty Hard Cases (2021–2023), for which she was nominated for a four Canadian Screen Awards.
In 2005, MacNeill appeared in series 3, episode 2 of Peep Show, playing the character of Mark and Jez's old friend from university, "Canadian" Merry.
[1] After writing episodes of This Hour Has 22 Minutes,[8] MacNeill starred in the films Big News from Grand Rock (2014), North Mountain (2015), and Your Money or Your Wife (2015).
[11] In 2021 MacNeill was cast as a police detective Sam Wazowski in the CBC comedy-drama series, Pretty Hard Cases opposite Adrienne C.