She is most remembered for her roles as Sally Morrison on My Three Sons (1963–1965) and as Billie Jo Bradley on Petticoat Junction (1966–1970).

MacRae made her breakthrough appearance as Sally Anne Morrison Douglas on the ABC (later CBS) Fred MacMurray/William Frawley sitcom, My Three Sons.

However, by MacRae's debut on the series, Billie Jo's persona was that of a strong, independent woman who focused more on a singing career, a dream she later accomplishes.

At first, the producers' intent was for Billie Jo and Steve Elliott, the Mike Minor character, to have a relationship and eventually marry.

She was a guest on NBC's The Spring Thing a musical television special hosted by Bobbie Gentry and Noel Harrison.

Other guests included Goldie Hawn, Irwin C. Watson, Rod McKuen, Shirley Bassey, and Harpers Bizarre.

[3] Her other film roles included appearances in Norwood (1970), My Friends Need Killing (1976), Grand Jury (1976), Sketches of a Strangler (1978), Earthbound (1981), and The Census Taker (1984).

; The Mike Douglas Show; The Rockford Files; Fantasy Island; Webster; CHiPS; The Fall Guy; Love, American Style; and Magnum, P.I.. MacRae was also popular in the game-show genre, appearing in numerous shows, including: Funny You Should Ask; Match Game ('60s, '70s, and '90s versions); What's My Line?

In 1994, she narrated the audio-book version of columnist Deboarah Laake's book Secret Ceremonies: A Mormon Woman's Intimate Diary of Marriage and Beyond.

[citation needed] MacRae worked to raise funds for such causes as the Children's Burn Foundation, the American Cancer Society, and United Cerebral Palsy.

[1] Solo The Girls from Petticoat Junction (Meredith MacRae, Linda Kaye Henning and Lori Saunders)