The west side at the time of the Land Run of 1889, and the east side when the Iowa, Sac and Fox, Kickapoo, Absentee Shawnee, and Citizen Band Potawatomi lands were opened in 1891. the Meridian Right-of-way and Townsite Company platted a town, which was incorporated in 1902.

[a] Sarah Harbor opened the first store in 1893, and sold it in 1895 to Miles William Allen, a successful claimant in the 1889 Land Run.

A post office opened in Harbor's store on March 10, 1894[4] In 1903 the Missouri, Kansas and Oklahoma Railroad (later the Missouri, Kansas and Texas Railway, Katy) built a branch line to Guthrie that passed through Meridian.

In March 1907 the Anti-Jim Crow Convention met in Meridian, where the main objective was to organize opposition to the proposed constitution for the State of Oklahoma.

[4] According to the United States Census Bureau, the town has a total area of 0.2 square mile (0.5 km2), all land.