[4] Wever starred in other television series, including Studio 60 on the Sunset Strip (2006–2007), New Girl (2013), The Walking Dead (2015–2016), and Severance (2025).

She has performed in theater productions, including Brooke Berman's play Smashing and Cavedweller with Deidre O'Connell, both off-Broadway.

[6] Wever appeared in numerous films, including Into the Wild, Neal Cassady, Michael Clayton, Series 7: The Contenders, Signs, The Adventures of Sebastian Cole, Bringing Rain, Tiny Furniture, and All I Wanna Do.

[10] She has guest-starred on a number of television series, including New Girl, The Good Wife, Conviction, Law & Order: Criminal Intent and The Wire.

She also starred in Ed Zwick's ill-fated pilot Quarterlife, with Rachel Blanchard, Austin Nichols and Shiri Appleby.

Her character's death toward the end of the sixth season of the series was controversial and sparked outrage on social media with many fans, most notably members of the LGBT community.

[15][16][17] Wever played a lead role in the miniseries Godless (2017) as Mary Agnes McNue, a tough leader of a female-dominated town.