She made her professional acting debut on the soap opera Guiding Light in 1997, where she played spoiled rich girl Drew Jacobs.
[2][3] She received glowing reviews for her performance[4] and earned an Emmy Award for Outstanding Supporting Actress in a Miniseries or a Movie.
[13][14] In 2008, she appeared in the multi-star cast of the television docudrama Living Proof as the first woman to have been treated with the breast cancer drug Herceptin.
[15] In 2010, Blanchard played Amy Roberts, the widow of a murderer, in the made-for-television film Amish Grace, which first aired on the Lifetime Movie Network.
[20] Blanchard played the role of "office bombshell Hedy La Rue" in the Broadway revival of How to Succeed in Business Without Really Trying, which opened on March 27, 2011, and closed on May 20, 2012.
[23][24] In 2014, Blanchard appeared as Florinda in director Rob Marshall's film, Into the Woods, an adaptation of the popular stage musical.