She later made minor appearances in the television series Notruf Hafenkante (2010) and Ein Fall für zwei (2010).

At the end of 2010, she was chosen by Meral Okay for her first leading role in the Turkish TV series Muhteşem Yüzyıl (2011–2013).

In addition to her acting career, Uzerli has appeared in many advertising films and is the face of numerous brands.

Uzerli's most known breakout role is as Hürrem Sultan in the historical television drama series Muhteşem Yüzyıl, directed by the Taylan Brothers.

[5] About her selection, she said: "Until one day the phone rang, I was invited for a casting in Turkey, and then immediately I started living in Istanbul almost full time.

[14][15] About her future, she says: "I am trying to build on my international success within any industry where actors are respected as artists, and where I can find great scripts that allow me to delve into a story that leaves the here and now behind.

"[6] In March 2015, it was finalized that Uzerli would share the leading role with Murat Yıldırım in her new TV series.

[22] In 2017, she continued her movie career by appearing in Cingöz Recai opposite Kenan İmirzalıoğlu, although the film was not a box office success.

[23] Later in the same year, she shared the leading role with Özcan Deniz and Aslı Enver in the movie Öteki Taraf.

[25] She also appeared as the lead role in the movie Kovan, the proceeds of which were donated to Haluk Levent's Ahbap foundation.