Mesagne (Mesagnese: Misciàgni) is a comune in the province of Brindisi and region of Apulia, on the south-east Italy coast.

Mesagne was an important center when Apulia was dominated by the Messapians, because it joined Oria to the port of Brindisi.

In the Middle Ages it was called Castrum Medianum, then Castro Misciano, this is the name used from the 16th century.

When Giovanni Antonio Orsini Del Balzo decided to expend the city's castle, Mesagne evolved, with the construction of a theater, a hospital and the paving of roads.

Carlo Molfetta was taekwondo gold medal in the 80+ kg category at the 2012 Summer Olympics of London.